How to Prevent the Common Cold

Avoid / Cure A Cold Fast

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Evolutionary Theodicy

- actually, RNA in the case of the common cold virus, but the principle is the same. A virus exists for the sole purpose of making more viruses. Well, the same is ultimately true of tigers and snakes, but there it doesn't seem so futile. The tiger and the snake may be DNA-replicating machines but they are beautiful, elegant, complicated, expensive DNA-replicating machines. I've given money to preserve the tiger, but who would think of giving money to preserve the common cold It's the futility of it that gets to me, as I blow my nose yet again and gasp for breath.

Gene Transfer in Intracellular Bacterial Parasites

Chlamydophila Trachomatis

Evidence for gene transfer has also been discovered in other intracellular pathogens, including Afipia, Brucella, Burkholderia, Francisella, Nocardia, Rhodococcus, Coxiella and Legionella 65-69 , which were previously thought to undergo minimal if any transformation or conjugation. Rhodococcus and Mycobacterium, although phylogenetically distinct based on 16S rRNA analyses, share a highly homologous haloalkane dehalo-genase gene. This gene has recently evolved and functions to degrade an environmental pollutant known as synthetic haloalkane 69 . Synthetic haloalkanes are used as refrigerants, solvents and fire extinguishing agents. Extensive gene transfer events, including recombination and rearrangement involving the methionyl-tRNA synthetase and methyl-directed mismatch repair (mutS) genes, have also been described for Brucella suis and Salmonella enterica SARB strains 8, 68 . Interestingly, mutS also functions to block foreign DNA insertion, serving as a barrier for horizontal gene...

The Apollo flights a brief history

Despite the operational success of the mission, history tends to remember this flight for the breakdown that occurred in relations between the crew and flight controllers in mission control. A dose of the common cold had made its normally wise-cracking commander increasingly grumpy. A cold in space is made more unpleasant by the inability of the congested head to drain itself. The other two crewmen, both rookies, were drawn into the soured atmosphere with the result that, having irritated management, neither of them flew in space again. Schirra had already announced his retirement from space flight.

Disease

In the last years of the twentieth century great attention was centered on human communicable diseases, sparked by a spate of movies and best-selling books. What are the chances that a new disease could bring about the extinction of humanity For instance, what if a 100 fatal disease such as HIV were spread as readily as the common cold And what if such a disease were used as a weapon Biological warfare, like nuclear warfare, does have the potential for a radical reduction of the human population if world war erupted. Most disturbing may be the stockpiling of diseases for which we no longer are vaccinated (e.g., smallpox), and the genetic engineering of new, virulent strains of disease, the subject of countless movie and book plots.

Final Four Hours

Seating for the crew put the command module pilot in the left seat as he had received most training for the re-entry procedures. None of the Apollo crews wore their pressure suits for re-entry after the Apollo 7 crew rebelled, citing their head colds as a reason not to have to wear the bulky garments. The CMP manoeuvred the spacecraft to an attitude that put the heatshield forward with the crew heads-down and looking back. It wasn't their final entry attitude a further pitch-up would be required for that - a manoeuvre they would execute a few minutes before reaching entry interface. But in this attitude, they could make checks of their attitude control and trajectory, and it was a starting point for the jettisoning of the service module.

Medical matters

Although the Apollo crews were drawn from a pool of very fit men, each of whom had undergone an exhaustive medical examination before being hired and again before the flight, they were nonetheless human and ended up suffering the normal range of minor illnesses and conditions during their flights that one would expect from any sample of healthy people. One perennial problem that afflicted the early flights was the common cold. It made life much harder for the Apollo 7 crew when they all contracted colds early in their 11-day flight, and it caused the launch of Apollo 9 to be delayed for three days to enable its crew to recover from a bout of sniffles and congested noses. Their susceptibility was attributed to their high work rate prior to launch, which sapped their immune system, and to the large numbers of people with whom they came into contact in those final weeks and days. Afterwards, NASA began to quarantine their crews to reduce the likelihood of their catching colds.

Coasting to the Moon

Throughout the early years of planning for the Apollo lunar flights, it had always been assumed that the best arrangement for sleep would be a rotation system in which at least one crew member would always be awake to monitor the systems. Apollo 7 followed this regime. Donn Eisele, the command module pilot, took his rest period alone. The commander Wally Schirra and lunar module pilot Walt Cunningham took theirs simultaneously. The crew never reported problems with this arrangement during their debriefing although any tiredness could have been masked by the irritating head colds that they endured and the irritability that they displayed could have been exacerbated by lack of sleep. In any case, Apollo 7 was confined to Earth orbit and its crew were not in the position of being the first humans to orbit another world for 20 hours.

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