Bibliography

Chapter 10: Elongation Cycle, Step I:

Aminoacyl-tRNA Binding 139

10.1. Codon-Anticodon Interaction 139

10.1.1. Adaptor Hypothesis and Its Proof 139

10.1.2. The Concept of Anticodon 139

10.1.3. Wobble Hypothesis 140

10.1.4. Corrections to Wobbling Rules 142

10.1.5. Stereochemistry of Codon-Anticodon Pairing 143

10.2. Participation of the Elongation Factor 1 (EF-Tu or eEF1A)

in Aminoacyl-tRNA Binding 144

10.2.1. EF1A and Its Interactions 144

10.2.2. Binding the Ternary Complex with the Ribosome 147

10.2.3. Role of GTP and Its Hydrolysis in the Catalysis of Aminoacyl- tRNA Binding 148

10.3. Inhibitors of Aminoacyl-tRNA Binding 149

10.3.1. Tetracyclines 150

10.3.2. Aminoglycosides 151

10.3.3. Some Indirect Inhibitors 152

10.4. Miscoding 153

10.4.1. Misreading of Poly(U) 153

10.4.2. Leakiness of Stop Codons 153

10.4.3. Principal Types of Mispairing 154

10.4.4. Factors Contributing to Miscoding 154

10.4.5. Miscoding Level In Vivo under Normal Conditions 155

10.4.6. Kinetic Mechanisms of Miscoding and Miscoding Correction. . . . 157

10.5. Summary: Sequence of Events and Molecular Mechanisms 158

10.5.1. Scanning of tRNA Species 158

10.5.2. Recognition of Anticodon 159

10.5.3. GTP Hydrolysis 159

10.5.4. EF-Tu (EF1A) Release and Correction of

Aminoacyl-tRNA Selection 159

10.5.5. Locking of Aminoacyl-tRNA in the A Site 160

10.5.6. General Scheme 160

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