Bibliography

Chapter 12: Elongation Cycle, Step III:

Translocation 175

12.1. Definition and Experimental Tests 175

12.2. Participation of the Elongation Factor 2 (EF-G or eEF2) in Translocation. . 176

12.2.1. EF2 Structure 176

12.2.2. EF2 Interactions 178

12.2.3. Translocation Intermediate 179

12.2.4. Role of GTP and Its Hydrolysis in the Catalysis of Translocation . 180

12.3. "Nonenzymatic" (Factor-Free) Translocation 180

12.4. Movement of the Template during Translocation 182

12.4.1. Triplet Translocation 182

12.4.2. Non-triplet Translocations (Translocation Errors) 182

12.4.2. l. Frameshifting at the Aminoacyl-tRNA Binding Step . . . .183 12.4.2.2. Frameshifting at the Translocation Step 184

12.4.3. Ribosome Hops 186

12.5. Mechanics and Energetics of Translocation 189

12.5.1. Stereochemistry and Mechanics 189

12.5.2. Energetics 189

12.6. Inhibitors of Translocation 190

12.6.1. Aminoglycosides and Aminocyclitols 190

12.6.2. Viomycin (Tuberactinomycin) 191

12.6.3. Thiostrepton 191

12.6.4. Fusidic Acid 192

12.6.5. Glutarimides 192

12.6.6. Non-specific Inhibitory Agents 192

12.7. Summary: Sequence of Events and Molecular Mechanisms 193

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