Bibliography

Chapter 17: Translational Control in Eukaryotes 283

17.1. Importance of Translational Control in Eukaryotes 283

17.2. Total Translational Regulation 283

17.2.1. Regulation by Modifications of Initiation Factors 283

17.2.1.1. Phosphorylation of Met-tRNA^GTP-binding

Factor (eIF2) 283

17.2.1.2. Phosphorylation of Cap-binding Factor (eIF4E) 286

17.2.2. Regulation by mRNP Formation 287

17.3. Discrimination of mRNAs 288

17.3.1. Discrimination by Initiating Ribosomal Particles 288

17.3.2. Discrimination by mRNA-Binding Initiation Factors 288

17.3.3. Modulation of Translational Discrimination by

Inhibiting Elongation 289

17.3.4. Modulation of Translational Discrimination by

Changing Initiation Rate 291

17.4. Regulation of Initiation by Upstream Open Reading Frames 291

17.4.1. ORF Sequence-Dependent Inhibition of Initiation 292

17.4.2. ORF-Mediated Regulation of Yeast Transcription Factor GCN4 . . 293

17.4.3. ORF-Involving Ribosome Shunting 295

17.5. Translational Repression 296

17.5.1. Iron-Responsive Regulation 296

17.5.2. Repression via Prevention of Helix Unwinding 297

17.5.3. Regulation of Ribosomal Protein mRNA Translation 299

17.5.4. Repression by Prevention of Initiation Complex

Movement along mRNA 300

17.6. mRNA Masking 300

17.6.1. Masked mRNA in Oocytes and Spermatocytes 300

17.6.2. mRNA Masking and Unmasking during Embryonic Development 302

17.6.3. mRNA Masking and Unmasking during Cell Differentiation 302

17.6.4. Masking and Unmasking of mRNA in Differentiated Cells 302

17.6.5. Models of mRNA Masking 303

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