Masking Proteins Localization Proteins Destabilization Proteins

Figure 2.6. Schematic representation of the distribution of mRNA-binding proteins among different regions of eukaryotic mRNA (Reproduced from A.S. Spirin, in "Translational Control", J.W.B. Hershey, M.B. Mathews & N. Sonenberg, eds., p.p. 319-334, CSHL Press, 1996, with permission).

translational activity. (2) Specifically in Eukaryotes, the mRNA-binding components involved in translation, such as ribosomes, translation initiation factors, translational repressors and activators, must interact with mRNPs, rather than with mRNAs. The pre-bound mRNP proteins may exert either competing (antagonistic) or attracting (synergistic) effect on the binding of the translation components to mRNA. (3) Numerous protein-protein interactions within mRNPs are very likely. This can create additional possibilities for three-dimensional folding and packaging of mRNPs thus controlling the accessibility of mRNA for translation, degradation, transporting systems, intracellular localization "anchors" and possible association with cytoskeleton structures.

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