Juc

Frequency 0.642 0.142 0.217

Measures of linkage disequilibrium for G and A alleles of rs909253 and rs1800629

Coefficient of linkage disequilibrium, D = deviation of observed frequency of haplotype from expected if genotypes independent

= frequency of haplotype GA - product of frequency of the two alleles rs909253G and rs1800629A

= PGA - Prs909253G Prs1800629A

= 0.217 - (0.358 x 0.217) = 0.139 D' = observed LD relative to the maximum possible deviation given allele frequencies

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