Jtk

0.0001 0.01 1 0.01 0.0001 Significance level (P)

Oxidoreductase

Select regulatory molecule

Transferase

Membrane traffic protein Lyase

Phosphatase Kinase

Nucleic acid binding

Synthase and synthetase

Isomerase

Ligase

Chaperone

Figure 9.9 Recombination rates vary with GC content, specific motif density, and in relation to start and end sites of transcription. (A) Recombination rates shown in relation to distance from transcriptional start and end sites, GC content, and density of a specific motif CCTCCCTNNCCAC (shown for all motifs varying by 1 bp from this consensus). (B) Recombination rates vary by gene category. Reprinted by permission from Macmillan Publishers Ltd: Nature (Frazer et al. 2007), copyright 2007.

0.0001 0.01 1 0.01 0.0001 Significance level (P)

and fat mass, to warfarin dose and circulating levels of human immunodeficiency virus (HIV) prior to the onset of acquired immune deficiency syndrome (AIDS) (www. genome.gov/GWAstudies).

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