Njc

Chromosome 8

Figure 4.3 Technology platforms used to detect copy number variation. Redon and colleagues used a CGH Whole Genome TilePath array with large insert clones covering 93.7% of the euchromatic human genome, and a comparative intensity analysis using a high density single nucleotide polymorphism (SNP) array. In this example, two male genomes were compared for all chromosomes (top panels), an individual chromosome (middle panels), or a window on chromosome 8 (bottom panels) showing in detail a 2 Mb duplication in one genome. Redrawn and reprinted by permission from Macmillan Publishers Ltd: Nature (Redon et al. 2006), copyright 2006.

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