Figure 11.7 Genome-wide association for asthma at 17q21 and expression of ORMDL3. (A) Data shown for the initial genome-wide scan of 994 cases and 1243 controls with the strength of association (plotted on y axis) by genomic location (plotted on x axis) for 317 447 SNPs. FDR, false discovery rate. (B) Detail of disease association to 17q21. (C) Association with ORMDL3 expression of the same SNP markers. Redrawn and reprinted by permission from Macmillan Publishers Ltd: Nature (Moffatt et al. 2007), copyright 2007.

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