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Figure 9.15 SNP associations at the FTO gene locus. Data for SNPs from a genome-wide association scan at FTO locus are shown for type 2 diabetes (top), body mass index (BMI) in type 2 diabetes patients (middle), and a plot of linkage disequilibrium between rs9939609 and SNPs from the International HapMap Project CEU panel of European geographic ancestry (bottom). From Frayling et al. (2007), reprinted with permission from AAAS. Gene plots with genomic location adapted from screenshot of UCSC Genome Browser (Kent et al. 2002) (http://genome.ucsc.edu/) (Human May 2004 Assembly).

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