Figure 12.6 Haplotypic structure of the extended MHC region. Analysis of sequence diversity and HLA typing in 361 individuals from four ethnic groups of differing geographic ancestry: YRI (African), CEU (European), CHB (Chinese), and JPT (Japanese) allowed the inferred haplotypic structure across the region to be deduced. Recombination hotspots (triangles) are shown for overall population, with non-redundant haplotypes (lines) shown for each ethnic group. Redrawn and reprinted by permission from Macmillan Publishers Ltd: Nature Genetics (de Bakker et al. 2006), copyright 2006.

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