Large scale SNP mapping and insights into recombination

Allelic recombination between homologous chromosomes at meiosis is a major source of genetic diversity.

Non-allelic homologous recombination also occurs but much more rarely and may be associated with chromosomal rearrangements and genomic disorders (Section 5.2). A number of studies established that recombination rates were highly variable across the genome in human populations. For example, analysis of family pedigrees in the Icelandic population using a dense set of microsatellite markers demonstrated this at a large scale resolution (Fig. 9.7A) (Kong et al. 2002). Variation was observed within individual chromosomes and between chromosomes. Recombination rates were much higher in shorter chromosomes, for example chromosomes 21 and 22 exhibited rates twice as high as chromosomes 1 and 2. Finer resolution

Figure 9.6 HapMap population panels. Individuals of different geographic ancestry were genotyped in the International HapMap Project: the four populations included in Phase I and II are shown in black boxes; those in Phase III in plain black text.

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