Mb

Neuroglobin

22q13.1

HBZ HBA2 HBA1 HBE1 HBG2 HBG1 HBD HBB

Z Li Mill

Haemoglobin

16p13.3 a globin cluster

11p15.5 ß globin cluster

Figure 6.8 Evolution of the globin superfamily. Schematic representation of the likely evolution of the globin superfamily by gene duplications. Myr, million years ago. Redrawn with permission from Strachan and Read (2004).

Proto-e

Proto-P

Proto-e

Proto-P

Inactivation Conversion of n of 8 by P

Duplication

Inactivation Conversion of n of 8 by P

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