Mbl Nosa

CD32, low affinity receptor for Fc fragment of IgG

HLA-B, a component of MHC class I

HLA-DR, a component of MHC class II

Interferon a receptor component

Interferon y

Interferon y receptor component

IL1A/IL1B Interleukin-1a and -1b IL1O Interleukin-10

Interleukin-12 ß subunit Interleukin-4

Clearance of antigen-antibody complexes

Antigen presentation that leads to cytotoxic T cells

Antigen presentation that leads to antibody production

Cytokine receptor

Cytokine with antiparasitic and proinflammatory properties

Cytokine receptor

Proinflammatory cytokines Anti-inflammatory cytokine Promotes development of Th1 cells Promotes antibody producing B cells

Mannose-binding protein Activates classic complement Inducible NO synthase Generates NO, a free radical

Tumour necrosis factor

TNFSF5 CD40 ligand

Cytokine with antiparasitic and proinflammatory properties

T cell-B cell interactions leading to immunoglobulin class switching

Association with severe malaria in The Gambia HLA-B53 association with severe malaria in The Gambia HLA-DRB1 association with severe malaria in The Gambia Association with severe malaria in The Gambia Weak associations with severe malaria in The Gambia Association with severe malaria in Mandinka people of The Gambia

Marginal associations with severe malaria in The Gambia Haplotypic association with severe malaria in The Gambia Association with severe malaria in Tanzania

Association with antimalarial antibody levels in Fulani people of Burkina Faso

Association with severe malaria in Gabon

Various associations with severe malaria in Gabon, The Gambia, and Tanzania

Various associations with severe malaria and reinfection risk in the Gambia, Kenya, Gabon, and Sri Lanka

Association with severe malaria in The Gambia

Host molecules mediating cytoadherence by parasitized red blood cells

Gene Protein Reported genetic associations with malaria

CD36 CD36 antigen, thrombospondin receptor

CR1 CR1, complement receptor 1

ICAM1 CD54, intercellular adhesion molecule-1

PECAM1 CD31, platelet-endothelial cell-adhesion molecule

CD36 polymorphisms show variable associations with severe malaria in The Gambia, Kenya, and Thailand

CR1 polymorphisms show variable associations with severe malaria in The Gambia, Thailand, and Papua New Guinea

ICAM1 polymorphisms show variable associations with severe malaria in Kenya, Gabon, and The Gambia

PECAM1 polymorphisms show variable associations with severe malaria in Thailand, Kenya, and Papua New Guinea

Function

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