Red cells resistant to
GATA-1 binding site lost merozoite invasion in presence of SNP
Loss of expression of DARC gene
DARC gene
Figure 13.6 Molecular schematic of the functional consequences of an A to G substitution in the promoter of the DARC gene. In the homozygous state, GATA-1 binding is lost and the DARC gene is not expressed. Red blood cells in these 'Duffy negative' individuals are resistant to invasion by Plasmodium vivax as the cells lack the Duffy antigen receptor required by the parasite to gain entry.
Figure 13.6 Molecular schematic of the functional consequences of an A to G substitution in the promoter of the DARC gene. In the homozygous state, GATA-1 binding is lost and the DARC gene is not expressed. Red blood cells in these 'Duffy negative' individuals are resistant to invasion by Plasmodium vivax as the cells lack the Duffy antigen receptor required by the parasite to gain entry.
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