Tapbp

Figure 12.1 Genes encoded within the MHC involved in the immune system. Over the 7.6 Mb of DNA sequence comprising the extended MHC, 28% of genes are estimated to be involved in different immune functions including innate and adaptive immunity. A selection of genes are shown here with arrows to functional groupings. The majority are concerned with antigen presentation and processing. These include classical MHC class I and II molecules, together with antigen processing machinery needed for loading peptides onto class I molecules.

Stress ^ response

HSPA1A,B,L

Complement cascade

Antigen presentation and processing

MHC class II molecules

MHC class II molecules

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