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Figure 5.10 Expected change in allele frequency due to reversible or two-way mutation for a diallelic locus for five initial allele frequencies. Here the chance that an A allele mutates to an a allele (A ^ a) is 0.0001 and the chance that an a allele mutates to an A allele (a ^ A) is 0.00005. These mutation rates are toward the high end of the range of estimated mutation rate values (see Table 5.1). The expected equilibrium value is p = 0.333 according to equation 5.22, an allele frequency that is reached only after tens of thousands of generations. The time to equilibrium is proportional to the absolute magnitudes of the mutation rates while the equilibrium value depends only on a function of the ratio of the mutation rates.

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