Protein Structure and Nucleic Acid Binding

The dynamics in the succession of stages of formation of the code follows a symmetry that builds the picture of a levorotatory windmill (Fig. 2). The extreme stages correspond to starting with the single class II-only pair of boxes (Gly with Pro) and ending with the single class I-only pair (Ile and Met with Tyr). Stage 1 contains three small and hydroapathetic amino acids in the hydropathy correlation outlier attributions (GPS). Five of the six amino acids in the final stages (3c and 4) are hydrophobic (CWIMY), only Thr being hydroapathetic. In the intermediate stages,

Fig. 2 The symmetry in the succession of integration of pairs into the system builds the dynamic picture of a levorotatory windmill. The drawing follows the matrix in Table 1B. The hydropathy outliers (flaps [1a] Pro:Gly; [1b] Ser:Ser [Arg]) conserve the central G and C, and the remaining pairs of the homogeneous pDiN sector are central A and U (flaps [2a] Asp, Glu:Leu; [2b] Asn, Lys:Phe [Leu]). Pairs 3a and 3b conserve the 3' G and C (flaps [3a] Ala:Arg; [3b] His, Gln:Val), and the remaining pairs of the mixed pDiN sector are the 3' A and U (flaps [3c] Thr:Cys, Trp; [4] Ile, Met:Tyr)

Fig. 2 The symmetry in the succession of integration of pairs into the system builds the dynamic picture of a levorotatory windmill. The drawing follows the matrix in Table 1B. The hydropathy outliers (flaps [1a] Pro:Gly; [1b] Ser:Ser [Arg]) conserve the central G and C, and the remaining pairs of the homogeneous pDiN sector are central A and U (flaps [2a] Asp, Glu:Leu; [2b] Asn, Lys:Phe [Leu]). Pairs 3a and 3b conserve the 3' G and C (flaps [3a] Ala:Arg; [3b] His, Gln:Val), and the remaining pairs of the mixed pDiN sector are the 3' A and U (flaps [3c] Thr:Cys, Trp; [4] Ile, Met:Tyr)

hydropathies are correlated with the anticodon complementarity. The main characters found relevant for formation of the code were the acquisition of metabolic stability by the proteins and their ability to bind to RNA, wherefrom an RNP system could be developed.

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