Axon Pathfinding

L Strochlic, C Weinl, M Piper, and C E Holt,

University of Cambridge, Cambridge, UK

© 2007 Elsevier Inc. All rights reserved.

1.12.1 Introduction

1.12.2 The Growth Cone: A Central Player in Axon Pathfinding

1.12.2.1 The Growth Cone is a Highly Dynamic Structure and Changes Its Shape in Response to Its Environment

1.12.2.2 Axon-Pathfinding Concepts

1.12.3 Growth Cone Guidance

1.12.3.1 Identification of Guidance Molecules

1.12.3.2 Guidance Cue Families

1.12.4 The Retinal Projection and the Midline Choice Point: Model Systems to Study Axon Pathfinding

1.12.4.1 The Retinal Projection as a Model System

1.12.4.2 The Midline Choice Point as a Model System

1.12.5 Modulation of Axon Guidance

1.12.5.1 Regulated Gene Expression

1.12.5.2 Post-Transcriptional Control

1.12.5.3 Local Translational Control

1.12.5.4 Local Protein Degradation and Endocytosis at the Growth Cone

1.12.5.5 Receptor Interaction

1.12.5.6 Implications for Axon Guidance

1.12.5.7 Axon Guidance and Evolution

1.12.6 Concluding Remarks

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