Conclusions

Studies on the cell biology of neuronal migration suggest that migrating neurons share many common mechanisms with other migrating cell types in the vertebrate body, although additional experiments are required to comprehensively decipher the cellular and molecular components of the migratory machinery in neurons. Regardless of the cell biological mechanisms, distinct modes of migration exist in the embryonic and adult brains, which seem to be adapted to fulfill different functions during evolution. Thus, whereas radial migration may have evolved as a mechanism to preserve the identity of different regions in the developing brain, tangential migration may have provided a means to increase the complexity of neural circuits during evolution.

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