Developmental Regulation of the AP

The results of several studies reveal three general developmental patterns of APs (Figure 5). The first two patterns, classes 1 and 2, have been studied more frequently and are relevant to the vast majority of neurons that continue to fire APs in the nervous system. These two patterns are distinguished on the basis of the ionic dependence of the impulse initially fired by a differentiating excitable cell (for review, see

Young neurons

Mature neurons

Mature neurons

Class 2

Class 3

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