Evolution of the Action Potential

RH Pineda and AB Ribera, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA

© 2007 Elsevier Inc. All rights reserved.

1.13.1 Introduction 212

1.13.2 What Are Action Potentials? 212

1.13.2.1 APs are Neuronal Signatures 213

1.13.2.2 AP Waveform Properties 213

1.13.3 Molecular Determinants of APs 214

1.13.4 Roles in Information Coding 215

1.13.4.1 Prior to Synapse Formation 215

1.13.4.2 During Synapse Formation and Early Circuit Activity 215

1.13.4.3 Mature Nervous System 216

1.13.5 Regulation of Excitability during Embryogenesis 216

1.13.6 Developmental Regulation of the AP 216

1.13.6.1 Class 1 Pattern of AP Development 217

1.13.6.2 Class 2 Pattern of AP Development 217

1.13.6.3 General Principles 217

1.13.7 Myelination 218

1.13.7.1 Function 218

1.13.7.2 Distribution of Ion Channels during Developmental Myelination 218

1.13.8 Mechanisms of Developmental Regulation 219

1.13.8.1 Transcriptional Regulation 219

1.13.8.2 Post-Transcriptional 226

1.13.8.3 Translational/Post-Translational 228

1.13.9 Future Studies 230

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