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i-Netrinn Slit

Robi Robo, Robo3 Robo, Robo2, Robo3

Netrin Slit -

Crossing axons attracted by netrin, insensitive to Slit. Noncrossing axons express cell-surface Robo, and are repelled from midline.

Crossing axons begin to express cell surface Robo and become sensitive to Slit.

High axonal expression of Robo drives growth cones from midline.

Differential expression of Robo proteins mediates selection of longitudinal fascicles.

Floorplate Netrin-1 Slit1,2,3

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