Protein therapeutics versus small molecule drugs

Small molecule drugs have several advantages, including oral bioavailability, ability to reach intracellular targets, ease of manufacturing, and generally a long shelf life. These characteristics make them favorable over protein drugs in the pharmaceutical industry (see the section titled Challenges in Pharmaceutical Translation of New Therapeutic Proteins, in this chapter). However, small molecule drugs, which typically have a molecular weight less than 1000 Daltons, have limited surface area...