Improvement of protein stability and folding

As mentioned previously, the secretion, folding, and stability of a protein all contribute to the efficiency with which it is displayed on phage particles, and thus these parameters play an important role in the success of phage display experiments. In addition, the dependence of phage display on these factors can be used to select for improved stability of a protein, and although phage display is not a true selection method for folding, it is nonetheless sensitive to folding.

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