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Second generation: 102 residues, a-helical, well folded

Second generation: 102 residues, a-helical, well folded

FIGuRE 11.5 (see color insert following page 178) Design of the first- and second-generation libraries of binary patterned four-helix bundles. The first generation library was designed to have 74 residues. In the second generation, each helix was extended by one helical turn leading to a 102-residue library. The design templates of the first- and second-generation four-helix bundle libraries differ in terms of number of total residues and the number and placement of combinatorially diverse residues. Polar residues are represented by red circles, nonpolar residues by yellow circles, and turn residues by blue circles. Residues that were held constant for the purposes of gene construction are coded with the single letter code, while combinatorial positions are colored but contain no letter.

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