The Yamagata-Rein hypothesis, that dates back to a publication of Yamagata (1966), with its challenging theoretical background, has provided an alternative fresh look on the origin of biomolecular asymmetry and thus attracted the interest of chirality's scientific community since decades (e.g. Keszthelyi 1984; Borchers et al. 2004). D- and L-enantiomers are in fact not the exact mirror images of each other but differ in scalar physicochemical properties. The parity non-conserving neutral current weak interaction causes parity-violating forces that give rise to different bond strengths in enantiomer molecules! If the electromagnetic interaction, which is mirror-image invariant, were the only force that binds electrons to atomic nuclei, the electronic binding energy of D- and L-enantiomers were identical. But the asymmetric weak interaction slightly interferes with the electromagnetic interaction stretching its tiny asymmetry from atomic nuclei towards atoms and molecules (Rein 1992).6
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