Ligand-binding sites may be identical when all sites in the macromolecule are empty, but when one site is occupied, the binding strength (i. e., the binding equilibrium constant) of the remaining sites changes. If the strength of binding increases with each additional ligand, this behavior is called cooperative binding. If subsequent additions of ligand to the same macromolecule are less strongly associated than its predecessors, the behavior is termed anticooperative.
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Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.